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3 edition of Physiological activity and clinical uses of ascorbic acid (vitamin C) found in the catalog.

Physiological activity and clinical uses of ascorbic acid (vitamin C)

Merck & Co.

Physiological activity and clinical uses of ascorbic acid (vitamin C)

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  • 4 Currently reading

Published by Merck in Rahway, New Jersey .
Written in English

    Subjects:
  • Vitamin C

  • Edition Notes

    Other titlesVitamin C.
    Classifications
    LC ClassificationsQP801.V5 M363513
    The Physical Object
    Paginationv.
    ID Numbers
    Open LibraryOL6423768M
    LC Control Number41022487
    OCLC/WorldCa2378085


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Physiological activity and clinical uses of ascorbic acid (vitamin C) by Merck & Co. Download PDF EPUB FB2

Get this from a library. Physiological activity and clinical uses of ascorbic acid (vitamin C). [Merck & Co.]. Ascorbic acid enters all cells. It “proceeds to take up the protein coats being manufactured by the virus nucleic acid, thus preventing the assembly of new virus units.” Cells expand, rupture and die, but there is no virus particles available to enter and infect new cells.

Vitamin C, also known as ascorbic acid and ascorbate, is a vitamin found in various foods and sold as a dietary supplement. It is used to prevent and treat scurvy. Vitamin C is an essential nutrient involved in the repair of tissue and the enzymatic production of certain neurotransmitters.

It is required for the functioning of several enzymes and is important for immune system ncy category: A (to RDA), C (above RDA).

Vitamin C, or ascorbic Physiological activity and clinical uses of ascorbic acid book, is an essential requirement for various physiological processes because of its reducing activity. Protein synthesis. L-ascorbic acid concentrations were tested from 5 to % (Figure 2).

pH was adjusted to Tissue lev-els of L-ascorbic acid increased and were maximal at 20%. For unknown reasons, concentration levels higher than 20% resulted in decreased tissue levels.

Kinetics Fifteen percent L-ascorbic acid at pH was applied daily for 1–5 days File Size: KB. Ascorbic acid (vitamin C, AA) is an essential nutrient of the human diet due to its participation on numerous regulatory and enzymatic processes.

Vitamin C (ascorbic Physiological activity and clinical uses of ascorbic acid book and L-ascorbic acid) is a vitamin found in food and used as a dietary supplement. As a supplement it is used to treat and prevent scurvy. Evidence does not support use in the general population for the prevention of the common cold.

It may be taken by mouth or Physiological activity and clinical uses of ascorbic acid book injection. It is generally well tolerated. Nutritional aspects of ascorbic acid: uses and abuses. Vilter RW. Ascorbic acid in physiological doses is essential for the normal functioning of the human body.

Larger doses are required to treat a severe deficiency of vitamin C intake, as in the case of scurvy. Occasionally, massive doses may be required to treat a metabolic defect involving Cited by: Ascorbic Acid is Physiological activity and clinical uses of ascorbic acid book natural water-soluble vitamin (Vitamin C).Ascorbic acid is a potent reducing and antioxidant agent that functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen in fibrous tissue, teeth, bones, connective tissue, skin, and capillaries.

Chemistry and biochemistry. Ascorbic acid (AscH 2, vitamin C) is a water-soluble ketolactone with two ionizable hydroxyl has two pK a ’s, pK 1 is and pK 2 is ; thus, the ascorbate monoanion, AscH −, is the dominant form at physiological pH (Fig.

1).Ascorbate is an excellent reducing agent and readily undergoes two consecutive, one-electron oxidations to form ascorbate Cited by: Food technological uses and applications The chemical properties of ascorbic acid provide a wide range of industrial applications.

The uses of ascorbic acid or vitamin C depend on its chemical properties as an antioxidant or on its health-related properties. Vitamin C is a water-soluble compound found in living organisms. It is an essential nutrient for various metabolism in our body and also serves as a reagent for the preparation of many materials in the pharmaceutical and food industry.

In this perspective, this chapter can develop interest and curiosity among all practicing scientists and technologists by expounding the details of its sources Cited by: 1. Ascorbic acid occurs naturally in foods such as citrus fruit, tomatoes, potatoes, and leafy n C is important for bones and connective tissues, muscles, and blood vessels.

Vitamin C also helps the body absorb iron, which is needed for red blood cell production/ Ascorbic Acid Technology in Agricultural, Pharmaceutical, Food, and Industrial Applications J. CHRISTOPHER BAUERNFEIND Chap DOI: /bach Publication Date (Print): June 1, Charles Chazot, Joel D. Kopple, in Nutritional Management of Renal Physiological activity and clinical uses of ascorbic acid book, Vitamin C.

Vitamin C (ascorbic acid, Table ), whose deficiency leads to scurvy, is oxidized to dehydroascorbic acid (DHAA) which also possesses antiscorbutic ic acid is mainly found in fresh fruits (e.g., blackcurrant, strawberry, lemon, orange, lime) and vegetables (e.g., broccoli, Brussels.

Do not take ascorbic acid (vitamin C) injection for longer than you were told by your doctor. Be careful if you have G6PD deficiency. Anemia may happen. Tell your doctor if you are pregnant or plan on getting pregnant.

You will need to talk about the benefits and risks of using ascorbic acid (vitamin C) injection while you are pregnant/ Ascorbic Acid has mistakenly been called Vitamin C - it is actually a liver metabolite rather than a vitamin.

It is produced in large quantities in almost all animals, e.g. 6 grams a day in a goat, or up to grams daily if the goat is stressed. But it is not Ascorbic Acid that our body requires, rather a. To determine any direct inhibitory effect of ascorbic acid, DHA or the combination of aspirin with ascorbic acid on COX enzymatic activity, an arachidonic acid assay was performed (Fiebich et al., ).

Briefly, SK-N-SH cells were plated in well cell culture plates and pre-incubated with IL-1 (10 U/ml) for 24 h.

Uses. Ascorbic acid is used to prevent or treat low levels of vitamin C in people who do not get enough of the vitamin from their people who eat a normal diet do not need extra ascorbic.

Vitamin C, an antioxidant, is found in food in the form of ascorbic acid (AA), its oxidizing form is known as dehydro ascorbic acid (DHAA), which has vitamin C activity, the reason for the.

Vitamin C is the first book to cover the history, chemistry, biochemistry, and medical importance of vitamin C and is the first to provide an in-depth, interdisciplinary study of this essential and fascinating compound.

The book provides a comprehensive and systematic account of the vitamin C story, fully surveying the history of scurvy and how its cure led to the suggestion, discovery, and.

Ascorbic acid (vitamin C) is the main hydrophilic radical scavenger present in the human body. Its antioxidant properties are related to its ability to generate a stabilized radical at its C-3 position because of the operation of the captodative effect (Fig. ).This allows ascorbic acid to react with harmful, more reactive species, particularly the hydroxyl radical, and prevent their.

Ascorbic Acid is a water-soluble vitamin recommended for the prevention and treatment of ic acid is available in generic form. Common side effects of ascorbic acid include transient mild soreness at the site of intramuscular or subcutaneous injection.

Too-rapid intravenous administration of the solution may cause temporary faintness or dizziness. In this series of booklets a great number of references are listed, abstracted, and classified so that information can be easily and rapidly found.

Each vitamin is dealt with under the following headings: (1) Chemical Investigation and Description; (2) Occurrence; (3) Physiological Activity, which includes the effects in experimental animals, in bacteria, in vitro in some cases, and in man.

The Use of Ascorbic Acid and Mineral Supplements in the Detoxification of Narcotic Addicts Valentine Free, M.A., 1 and Pat Sanders, R.N.

2 Since its inception inthe San Francisco Drug Treatment Program, Inc., has responded to the mental and physical health needs of narcotic addicts. The search for safer, cost-effectiveCited by: Overview Information Pantothenic acid is a vitamin, also known as vitamin B5.

It is widely found in both plants and animals including meat, vegetables, cereal grains, legumes, eggs, and milk. Physiological and Chemical Studies on Ascorbic Acid of Fruits and Vegetables object of this experiment is to illustrate the relation between the occurrence of chilling injury and the decrease of L-ascorbic acid (ASA) content in the seeds of stored sweet pepper fruit.

The polyphenoloxidase activity increased gradually during storage at 1. For example, intake of vitamin C, but not vitamin E, inhibits oxidized LDL-induced leukocyte adhesion to endothelium in hamsters Physiological concentrations of ascorbic acid also increase synthesis and activity of NO in vitro Vitamin C also inhibits activation of nuclear factor-B (NF- a key regulator of inflammatory gene expression 3) When shikimic acid, chlorogenic acid and dopa as browning substrates were added to okura peel tissues at 1°C, the browning in tissues advanced, but DKG content was rather decrease.

On the other hand, the addition of oxalic acid that is a final product in ascorbic acid oxidation effectively caused the accumulation of L-dehydro-ascorbic acid. Vitamin C (ascorbic acid) is a water-soluble vitamin, which is necessary in the body to form collagen in bones, cartilage, muscle, and blood vessels and aids in the absorption of iron.

Dietary sources of vitamin C include fruits and vegetables, particularly citrus fruits such as oranges. Severe deficiency of File Size: 76KB. Ascorbic acid is one of the important water soluble vitamins.

It is essential for collagen, carnitine and neurotransmitters biosynthesis. Most plants and animals synthesize ascorbic acid for their own requirement. However, apes and humans can not synthesize ascorbic acid due to lack of an enzyme gulonolactone oxidase. Hence, ascorbic acid has to be supplemented mainly through fruits Author: K Akhilender Naidu.

Ascorbic acid exists as two enantiomers (mirror-image isomers), commonly denoted "l" (for "levo") and "d" (for "dextro").The l isomer is the one most often encountered: it occurs naturally in many foods, and is one form ("vitamer") of vitamin C, an essential nutrient for humans and many ency of vitamin C causes scurvy, formerly a major disease of sailors in long sea voyages.E number: E (antioxidants, ).

Ascorbic Acid What Is It. Ascorbic acid (vitamin C) is a powerful antioxidant and offers a wide range of support for the human body. It provides support for numerous physiological functions, including vascular integrity and immune function.* Uses For Ascorbic Acid Cellular Function: Vitamin C.

Why getting vitamin C through ascorbic acid is a problem According to an article in The Healthy Home Economist, ascorbic acid is actually synthetic vitamin C, usually derived from GMO corn.

And, there is a growing body of evidence that those consuming high doses of ascorbic acid should have reason to worry. -The clinical value of ascorbic acid in combating shock is explained by the inhibition of deaminizing enzymes from the damaged cells by vitamin C.

Conditions of shock and stress cause depletion of the ascorbic acid content of the plasma. As with the virus bodies, ascorbic acid also joins with the protein factor of these toxins effecting quick.

Irwin Stone explains in his book on vitamin C that, 'Throughout the evolution of the vertebrates, including the mammals, Nature has used ascorbic acid to maintain physiological homeostasis. In simple nontechnical terms, this means that when stressful situations arose which disturbed the biochemical equilibrium of the animal, ascorbic acid was.

Its Effects on Photodamaged Skin Topography Steven S. Traikovich, DO Objective: To determine the efficacy of topical ascor-bic acid application in treating mild to moderate pho-todamage of facial skin using an objective, computer-assisted image analysis of skin surface topography and subjective clinical, photographic, and patient self-Cited by:   Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin that is naturally present in some foods, added to others, and available as a dietary supplement.

Humans, unlike most animals, are unable to synthesize vitamin C endogenously, so it is an essential dietary component [ 1 ]. Vitamin C is required for the biosynthesis of collagen.

Within 3 to 5 months of ascorbic acid deficiency, clinical signs of scurvy become evident. Distribution: Distributed widely in the body, with large concentrations found in the liver, leukocytes, platelets, glandular tissues, and lens of the eye.

Ascorbic acid crosses the placental barrier; cord blood levels are usually two to four times the. Cowan and Fallon even go so far as to say in this book that “ascorbic acid is not a food for us; that which it preserves is our food.” (Cowan and others p.

21) Too much “synthetic” ascorbic acid is harmful, the naturalists assert, especially when not accompanied by the vitamin C-complex. Ascorbic acid is an organic pdf related glucose, is pdf of the basic substances in the human diet essential for normal functioning of the connective and bone tissues.

It performs biological functions of a reducing agent and coenzyme in some metabolic processes, is an antioxidant. Its biologically activity is due to only one L-ascorbic acid isomers, which is referred to as Vitamin C.

Mice ( months old) treated with ascorbic acid once a week during three months showed an increase in the percentage of myelinating nerve fibers and showed better results in locomotor tests.

In this phase 2 study we will study the efficacy and .Vitamin Ebook (ascorbic acid or l-ascorbate) is nature’s most potent, safer antioxidant cofactor. Ascorbate has gotten a fair amount of attention from the media in the last few years, including whether it is helpful, neutral, or harmful in limiting the number of colds, their symptoms, and their duration.